Bo Li

Bo Li

Assistant Professor of Medicine, Assistant Investigator and Director of Bioinformatics and Computational Biology Program

Harvard Medical School and Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital

Li Lab

The Li Lab aims at developing novel computational tools to empower single-cell and single-nucleus multi-omics data analysis. Currently, we have three important research directions:

  • Cloud-based analysis of large-scale single-cell and single-nucleus RNA-seq datasets;
  • Cloud-based large-scale single-cell ATAC-seq data analysis;
  • Cloud-based spatial transcriptomics data analysis.

In addition, collaborating with biologists and clinicians, we also work on biological questions related to:

  • Human Immune Cell Atlas;
  • Human Tumor Cell Atlas;
  • COVID-19 research.

Recent News

Meet the Team

Principal Investigator


Bo Li

Assistant Professor of Medicine and Director of Bioinformatics and Computational Biology Program



Yiming Yang

Computational Scientist


Hui Ma

Co-Op Student


Kamil Slowikowski

Postdoctoral Fellow

Recent Publications

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A Single-Cell and Single-Nucleus RNA-Seq Toolbox for Fresh and Frozen Human Tumors

Single-cell genomics is essential to chart tumor ecosystems. Although single-cell RNA-Seq (scRNA-Seq) profiles RNA from cells …

Thousands of Novel Unannotated Proteins Expand the MHC I Immunopeptidome in Cancer

Tumor epitopes – peptides that are presented on surface-bound MHC I proteins - provide targets for cancer immunotherapy and have been …

Linking Indirect Effects of Cytomegalovirus in Transplantation to Modulation of Monocyte Innate Immune Function

Cytomegalovirus (CMV) is an important cause of morbidity and mortality in the immunocompromised host. In transplant recipients, a …

Integrated scRNA-Seq Identifies Human Postnatal Thymus Seeding Progenitors and Regulatory Dynamics of Differentiating Immature Thymocytes

During postnatal life, thymopoiesis depends on the continuous colonization of the thymus by bone-marrow-derived hematopoietic …

Cumulus: A Cloud-based Data Analysis Framework for Large-scale Single-Cell and Single-Nucleus RNA-seq

Massively parallel single-cell and single-nucleus RNA-seq (sc/snRNA-seq) have opened the way to systematic tissue atlases in health and …


  • bli28 [at] mgh [dot] harvard [dot] edu
  • CNY 149-8, 149 13th Street, Charlestown, MA 02129, United States