Bo Li

Bo Li

Assistant Professor of Medicine, Assistant Investigator and Director of Bioinformatics and Computational Biology Program

Harvard Medical School and Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital

Li Lab

The Li Lab aims at developing novel computational tools to empower single-cell and single-nucleus multi-omics data analysis. Currently, we have three important research directions:

  • Cloud-based analysis of large-scale single-cell and single-nucleus RNA-seq datasets;
  • Cloud-based large-scale single-cell ATAC-seq data analysis;
  • Cloud-based spatial transcriptomics data analysis.

In addition, collaborating with biologists and clinicians, we also work on biological questions related to:

  • Human Immune Cell Atlas;
  • Human Tumor Cell Atlas;
  • COVID-19 research.

Recent News

Welcome co-op students Linhui Chen and Dongyu Zhou joining our lab!

Linhui Chen and Dongyu Zhou officially join Li Lab today. Hope they have an enjoyable and fruitful time here!

Cumulus featured workspace on Terra is updated

The Cumulus featured workspace on Terra platform has been updated. Users who are interested in using cloud computing for single-cell data analysis can take it as an example to learn about Cumulus.

Cumulus is introduced in Pfizer Workshop

Yiming Yang and Hui Ma from Li Lab has taken the lead in a tutorial workshop for Pfizer researchers working on single-cell analysis, which was coordiated by Verily Life Science.

The Cumulus paper is published!

Cumulus paper is published in Nature Methods journal. You can find the paper here.

Welcome co-op student Hui Ma joining our lab!

Hui Ma officially joins Li Lab today. Although this is a tough time all over the country, hope she could have a time learning a lot and having fun in our lab!

Meet the Team

Principal Investigator


Bo Li

Assistant Professor of Medicine and Director of Bioinformatics and Computational Biology Program



Yiming Yang

Computational Scientist


Dongyu Zhou

Co-Op Student


Hui Ma

Co-Op Student


Kamil Slowikowski

Postdoctoral Fellow


Linhui Chen

Co-Op Student

Recent Publications

Quickly discover relevant content by filtering publications.

Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells

Myeloproliferative neoplasms (MPNs) are blood cancers that are characterized by the excessive production of mature myeloid cells and …

Cumulus provides cloud-based data analysis for large-scale single-cell and single-nucleus RNA-seq

Massively parallel single-cell and single-nucleus RNA-seq (sc/snRNA-seq) have opened the way to systematic tissue atlases in health and …

A Single-Cell and Single-Nucleus RNA-Seq Toolbox for Fresh and Frozen Human Tumors

Single-cell genomics is essential to chart tumor ecosystems. Although single-cell RNA-Seq (scRNA-Seq) profiles RNA from cells …

Thousands of Novel Unannotated Proteins Expand the MHC I Immunopeptidome in Cancer

Tumor epitopes – peptides that are presented on surface-bound MHC I proteins - provide targets for cancer immunotherapy and have been …

Linking Indirect Effects of Cytomegalovirus in Transplantation to Modulation of Monocyte Innate Immune Function

Cytomegalovirus (CMV) is an important cause of morbidity and mortality in the immunocompromised host. In transplant recipients, a …


  • bli28 [at] mgh [dot] harvard [dot] edu
  • CNY 149-8, 149 13th Street, Charlestown, MA 02129, United States