Li Lab @ MGH

Publication

*corresponding author; #co-first author

  1. Kang J, Rhee J, Wang C, Yang Y, Li G, Li H*. Unlocking the dark matter: noncoding RNAs and RNA modifications in cardiac aging. Am J Physiol Heart Circ Physiol, 2024;326(3):H832-44.
  2. Hastings M, Zhou Q, Wu C, Shabani P, Huang S, Yu X, Singh A, Guseh S, Li H, Lerchenmuller C, Rosenzweig A. Cardiac aging: from hallmarks to therapeutic opportunities. Cardiovasc Res. 2024; (Epub ahead of print)
  3. Liu X#, Li H#, Hastings M, Xiao C, Damilano F, Platt C, Lerchenmüller C, Zhu H, Wei X, Yeri A, Most P, Rosenzweig A. miR-222 inhibits pathological cardiac hypertrophy and heart failure. Cardiovasc Res, 2024;120(3):262-72.
  4. Rhee J, Freeman R, Roh K, Lyons M, Xiao C, Zlotoff D, Yeri A, Li H, Guerra J, Guseh J, Kuznetsov A, Houstis N, Roh J, Damilano F, Liu X, Silverman M, Kwong R, Das S, Rosenzweig A. Cardioprotective and anti-inflammatory effects of FAM3D in myocardial ischemia-reperfusion injury. Circ Res. 2023;133(7):651-3.
  5. Hastings M, Castro C, Freeman R, Kadir A, Lerchenmuller C, Li H, Rhee J, Roh K, Roh J, Xia P, Singh A, Wu C, Zhou Q, Xiao J, Rosenzweig A. Intrinsic and extrinsic contributors to the cardiac benefits of exercise. JACC Basic Transl Sci. 2023;18,9(4):535-52.
  6. Xiao X, Chen S, Huang Z, Han X, Dou C, Wang T, Xie H, Zhang L, Hei Z, Li H*, Yao W*. SerpinB1 is required for Rev-erba-mediated protection in sepsis-induced acute lung injury. Br J Pharmacol. 2023;180(24):3234-53.
  7. Yang J, Chen C, Miao X, Wang T, Guan Y, Zhang L, Chen S, Zhang Z, Xia Z, Kang J, Li H*, Yin T*, Hei Z*, Yao W*. Injury site specific xenon delivered by platelet membrane-mimicking hybrid microbubbles to protect against acute kidney injury via inhibition of cellular senescence. Adv Healthc Mater. 2023:e2203359.
  8. Trager L, Lyons M, Kuznetsov A, Sheffield C, Roh K, Freeman R, Rhee J, Guseh J, Li H, Rosenzweig A. Beyond cardiomyocytes: potential role of cellular diversity in the heart’s response to exercise. J Sport Health Sci. 2023;12(4):423-37.
  9. Li H, Trager L, Liu X, Hastings M, Xiao X, Guerra J, To S, Li G, Yeri A, Rodosthenous R, Silverman M, Das S, Ambardekar A, Bristow M, Gonzalez-Rosa JM, Rosenzweig A. lncExACT1 and DCHS2 regulate physiological and pathological cardiac hypertrophy. Circulation. 2022;145:1218-33.
  10. Sheffield C, Rosenzweig A, Li H*. The beauty of complexity: diverse roles of ZFAS1 in cardiac disease. JACC Basic Transl Sci. 2022,7(9):896-8. (Editorial)
  11. Lerchenmuller C, Vujic A, Mittag S, Wang A, Rabolli C, Heb C, Betge F, Rangrez A, Chaklader M, Guillermier C, Gyngard F, Roh J, Li H, Steinhauser M, Frey N, Rothermel B, Dieterich C, Rosenzweig A, Lee R. Restoration of cardiomyogenesis in aged mouse hearts by voluntary exercise. Circulation.2022,146(5):412-26.
  12. Hastings M, Herrera J, Guseh S, Atlason B, Houstis N, Kadir A, Li H, Sheffield C, Singh A, Roh J, Day S, Rosenzweig A. Animal models of exercise from rodents to pythons. Circ Res. 2022;130(12):19942014.
  13. Li G, Manning AC, Bagi A, Yang X, Gokulnath P, Spanos M, Howard J, Chan P, Sweeney T, Kitchen R, Li H, Laurent B, Aranki S, Kontaridis M, Laurent L, Keuren-Jensen K, Muehlschlegel J, Lowe T, Das S. Distinct stress-dependent signatures of cellular and extracellular tRNA-derived small RNAs. Adv Sci (Weinh). 2022, 2200829:5-20.
  14. Eder R, Boomen M, Yurista S, Rodriguez-Aviles Y, Islam M, Chen Y, Trager L, Coll-Font J, Cheng L, Li H, Rosenzweig A, Wrann C, Nguyen C. Exercise-induced CITED4 expression is necessary for regional remodeling of cardiac microstructural tissue helicity. Commun Biol. 2022, 5(1):656.
  15. Li H, Sheffield C, Guseh S, Rosenzweig A. Backhanded complement: circulating exosomes in aged animals add insult to injury after stroke. exRNA. 2021;3;10. (Editorial)
  16. Wu S, Yang J, Sun G, Hu J, Zhang Q, Cai J, Yuan D, Li H*, Hei Z*, Yao W*. Macrophage extracellular traps aggravate iron overload-related liver ischemia/reperfusion injury. Br J Pharmacol. 2021,178(18):3783-96.
  17. Li H*, Rosenzweig A. Understanding heart failure with preserve ejection fraction in a diabetic way. JACC Basic Transl Sci. 2021,6(2):100-2. (Editorial)
  18. Tai LW, Sun L, Li H, Gu P, Jossten E, Cheung CW. Additive effects of environmental enrichement and ketamine on neuropathic pain relief by reducing glutamatergic activation in spinal cord injury in rat. Front Neurosci. 2021,15:635187.
  19. Li H, Hastings M, Rosenzweig A. Exercise training in diabetes: Start earilier or exercise harder. Circ Res. 2020,127(11):1401-03. (Eidtorial)
  20. Li H, Hastings M, Rhee J, Trager L, Roh J, Rosenzweig A. Targeting age-related pathways in heart failure. Circ Res. 2020,126:533-51.
  21. Roh J, Houstis N, Yu A, Chang B, Yeri A, Li H, Hobson R, Lerchenmuller C, Vujic A, Chaudhari V, Damilano F, Platt C, Zlotoff D, Lee R, Shah R, Jerosch-herold M, Rosenzweig A. Exercise training reverses cardiac aging phenotypes associated with heart failure with preserved ejection fraction in male mice. Aging Cell 2020, 19(6):e13159.
  22. Yao W, Han X, Ge Mian, Chen C, Li H*, Hei Z*. N6-methyladenosine (m6A) methylation in ischemia-reperfusion injury. Cell Death Dis 2020,11:478.
  23. Zhu Q#, Li H#, Xie X, Chen X, Ramoji K, Li S, Lian Q, Cheung CW, Irwin MG, Ge R, Xia Z. Adiponectin facilitates postconditioning cardioprotection through both AMPK-dependent nuclear and AMPK-independent mitochondrial STAT3 activation. Oxid Med Cell Longev 2020,2020:4253457.
  24. Yao W, Han X, Guan Y, Guan J, Wu S, Chen C, Li H*, Hei Z*. Neutrophil elastase inhibitiors suppress oxidative stress in lung during liver transplantation. Oxid Med Cell Longev 2019, 2019: 7323986.
  25. Yao W, Guo A, Han X, Wu S, Chen C, Luo C, Li H*, Li S*, Hei Z*. Aerosol inhalation of a hydrogen-rich solution restored septic renal function. Aging (Albany NY) 2019,11(24):12097-113.
  26. Wang T, Shi M, Liao X, Li Y, Yuan H, Li Y, Liu X, Ning D, Peng Y, Yang F, Mo Z, Jiang Y, Xu Y, Li H, Wang M, Ou Z, Xia Z, Ou J. Overexpression of inducible intric oxide synthase in the diabetic heart compromises ischemic postconditioniong. J Mol Cell Cardiol 2019, 129:144-153.
  27. Yao W, Wai T, Hei Z, Liu Y, Li H. Oxidative stress and inflammation interaction in ischemia reperfusion injury: role of programmed cell death. Oxid Med Cell Longev 2019,2019:6780816. (Editorial)
  28. Li H*, Xia Z, Chen Y, Qi D, Zheng H. Mechanism and therapies of oxidative stress-mediated cell death in ischemia reperfusion injury. Oxid Med Cell Longev 2018,2018:2910643. (Editorial)
  29. Wu Q, Wang T, Chen S, Zhou Q, Li H, Hu N, Feng Y, Dong N, Yao S,  Xia Z. Cardiac protective effects of remote ischaemic preconditioning in children undergoing tetralogy of fallot repair surgery: a randomized controlled trial. Eur Heart J 2018, 39(12):1028-37.
  30. Wang CY, Li H, Wang S, Mao XM, Yan D, Wong SS, Xia Z, Irwin MG. Repeated Non-invasive Limb Ischemic Preconditioning Confers Cardioprotection Through PKC-e/STAT3 Signaling in Diabetic Rats. Cell Physiol Biochem 2018, 54(50):2017-21.
  31. Xie X, Yan D, Li H, Zhu Q, Li J, Fang YP, Cheung CW, Irwin MG, Xia Z, Lian Q. Enhancement of adiponectin ameliorates non-alcoholic fatty liver disease via inhibition of FoxO1 in type 1 diabetic rats. J Diabetes Res 2018, 2018:6254340.
  32. Sun L, Li H, Tai WL, Gu P, Cheung CW. Adiponectin regulates thermal nociception in a mouse model of neuropathic pain. Br J Anaesth 2018, 120(6):1356-67.
  33. Tai LW, Pan Z, Sun L, Li H, Gu P, Wong SSC, Chung SK, Cheung CW. Suppression of Pax2 attenuates allodynia and hyperalgesia through ET-1-ETAR-NFAT5 signaling in a rat model of neuropathic pain. Neuroscience 2018, 27(384):139-51.
  34. Deng F, Wang S, Zhang L, Xie X, Cai S, Li H, Xie GL, Miao HL, Yang C, Liu X, Xia Z. Propofol through upregulating caveolin-3 attenuates post-hypoxic mitochondrial damage and cell death in H9C2 cardiomyocytes during hyperglycemia. Cell Physiol Biochem 2017, 44(1):279-92.
  35. Yao W, Li H, Luo G, Li X, Chen C, Yuan D, Chi X, Xia Z, Hei Z. SERPINB1 Ameliorates Acute Lung Injury in Liver Transplantation Through ERK1/2-mediated STAT3-dependent HO-1 Induction. Free Radic Biol Med 2017, 108:542-53.
  36. Yao W#, Li H#, Han X#, Chen C, Zhang Y, Tai W, Xia Z, Hei Z. MG53 anchored by dysferlin to cell membrane reduces hepatocytes apoptosis which induced by ischemia/reperfusion injury in vivo and in vitro. J Cell Mol Med 2017, 21(10): 2503-13.
  37. Ge M, Yao W, Yuan D, Zhou S, Chen X, Zhang Y, Li H, Xia Z, Hei Z. Brg1-mediated Nrf2/HO-1 pathway activtion alleviates hepatic ischemia-reperfusion injury. Cell Death Dis 2017, 8(6): e2841.
  38. Wang S, Wang C, Yan F, Wang T, He Y, Li H, Xia Z, Zhang Z. N-Acetylcysteine attenuates diabetic myocardial ischemia reperfusion injury through inhibiting excessive autophagy. Mediators Inflamm 2017: 9257291.
  39. Gao S, Zhan L, Yang Z, Shi R, Li H, Xia Z, Yuan S, Wu Q, Wang T, Yao S. Remote limb ischemic postconditioning protects against myocardial ischemia/reperfusion injury in mice: activation of JAK/STAT3 mediated Nrf2-antioxidant signaling. Cell Physiol Biochem 2017, 43(3):1140-51.
  40. Li H, Yao W, Liu Z, Xu A, Huang Y, Ma XL, Irwin MG, Xia Z. Hyperglycemia abrogates ischemic postconditioning cardioprotection by impairing AdipoR1/Caveolin-3/STAT3 signaling in Diabetic Rats. Diabetes 2016, 65(4):942-55.
  41. Wang Y#, Li H#, Huang H, Liu S, Irwin MG, Xia Z. Cardioprotection from emulsified isoflurane postconditioning is lost in rats with streptozotocin-induced diabetes due to the impairment of Brg1/STAT3 signaling. Clin Sci (Lond) 2016,130(10):801-12.
  42. Xia Z, Li H, Irwin MG. Myocardial ischaemia reperfusion injury: the challenge of translating ischaemic and anaesthetic protection from animal models to humans. Br J Anaesth 2016, 117(Suppl. 2):44-62.
  43. Wang L, Wang T, Li H, Liu Q, Zhang Z, Xie W, Feng Y, Socorburam T, Wu G, Xia Z, Wu Q. Receptor interacting protein 3-mediated necroptosis promotes lipopolysaccharide-induced inflammation and acute respiratory distress syndrome in mice. PLoS One 2016,11(5):e0155723.
  44. Kandula V, Kosuru R, Li H, Yan D, Zhu Q, Lian Q, Ge RS, Xia Z, Irwin MG. Forkhead box transcription factor 1: role in the pathogenesis of diabetic cardiomyopathy. Cardiovasc Diabetiol 2016, 15(1):44.
  45. Han X, Yao W, Liu Z, Li H, Zhang Z, Hei Z, Xia Z. Lipoxin A4 preconditioning attenuates intestinal ischemia reperfusion injury through Keap1/Nrf2 pathway in a lipoxin A4 receptor independent manner. Oxid Med Cell Longev 2016,2016:9303606.
  46. Lin J, Wang T, Li Y, Wang M, Li H, Xia Z, Irwin MG. N-Acetylcysteine restores sevoflurane postconditioning cardioprotection against myocardial ischemia reperfusion injury in diaebtic rats. J Diabetes Res 2016,2016:9213034.
  47. Gao S, Yang Z, Shi R, Xu D, Li H, Xia Z, Wu QP, Yao S, Wang T, Yuan S. Diabetes blocks the cardioprotective effects of sevoflurane postconditioning by impairing Nrf2/Brg1/HO-1 signaling. Eur J Pharmacol. 2016,779:111-21.
  48. Gao S, Zhu Y, Li H, Xia Z, Wu Q, Yao S, Wang T. Remote ischemic postconditioning protects against renal ischemia/reperfusion injury by activation of T-LAK-cell-originated protein kinase (TOPK)/PTEN/Akt signaling pathway mediated anti-oxidation and anti-inflammation. Int Immunopharmacol. 2016, 38:395-401.
  49. Pang L, Cai Y, Tang EH, Yan D, Kosuru R, Li H, Irwin MG, Ma H, Xia Z. Cox-2 Inhibition Protects against Hypoxia/Reoxygenation-Induced Cardiomyocyte Apoptosis via Akt-Dependent Enhancement of iNOS Expression. Oxid Med Cell Longev 2016;2016:3453059.
  50. Li H, Yao W, Irwin MG, Wang T, Wang S, Zhang L, Xia Z. Adiponectin ameliorates hyperglycemia-induced cardiac hypertrophy and dysfunction by concomitantly activating Nrf2 and Brg1. Free Radic Biol Med 2015, 84:311-21.
  51. Tian Y#, Li H#, Liu P, Xu J, Irwin MG, Xia Z, Tian G. Captopril pretreatment produces an additive cardioprotection to isoflurane preconditioning in attenuating myocardial ischemia reperfusion injury in rabbits and in humans. Mediators Inflamm 2015:819232.
  52. Gan X, Xing D, Su G, Li S, Luo C, Irwin MG, Xia Z, Li H*, Hei Z*. Propofol attenuates small intestinal ischemia reperfusion injury through inhibiting NADPH oxidase mediated mast cell activation. Oxid Med Cell Longev 2015:167014.
  53. Zhou M, Bao Y, Li H, Pan Y, Shu L, Xia Z, Wu D, Lam KSL, Vanhoutte PM, Xu A, Jia W, Hoo R. Deficiency of adipocyte fatty acid binding protein alleviates myocardial ischemic reperfusion injury and diabetes-induced cardiac dysfunction. Clin Sci (Lond) 2015, 129(7):547-59.
  54. Liu Y, Jin J, Qiao S, Lei S, Liao S, Ge ZD, Li H, Irwin MG, Xia Z. Inhibition of PKC beta2 overexpression ameliorates myocardial ischemia/reperfusion injury in diabetic rats via restoring caveolin-3/Akt signaling. Clin Sci (Lond) 2015, 129(4):331-4.
  55. Luo C, Yuan D, Li X, Yao W, Luo G, Chi X, Li H, Irwin MG, Xia Z, Hei Z. Propofol attenuated acute kidney injury after orthotopic liver transplantation via inhibiting gap junction composed of connexin 32. Anesthesiology 2015, 122(1):72-86.
  56. Zhao W,Liu Z, Yu X, Lai L, Li H, Liu Z, Li L, Jiang S, Xia Z, Xu SY. iTRAQ proteomics analysis reveals that PI3K is highly associated with bupivacaine-induced neurotoxicity pathways. Proteomics 2015,16(4):564-75.
  57. Li S, Xu J, Yao W, Li H, Liu Q, Xiao F, Iriwn MG, Xia Z, Ruan W. Sevoflurane pretreatment attenuates TNF-α-induced human endothelial cell dysfunction through activating eNOS/NO pathway. Biochem Biophys Res Commun 2015, 469(3):879-86.
  58. Xia R, Xu J, Yin H, Wu H, Xia Z, Zhou D, Xia ZY, Zhang L, Li H, Xiao X. Intravenous infusion of dexmedetomidine combined isoflurane inhalation reduces oxidative stress and potentiates hypoxia pulmonary vasoconstriction during one-lung ventilation in patients. Mediators Inflamm 2015:238041.
  59. Xu J, Li H, Irwin MG, Xia ZY, Mao X, Lei S, Wong GT, Huang V, Cheung CW, Fang X, Clanachan AS, Xia Z. Propofol ameliorates hyperglycemia-induced cardiac hypertrophy and dysfunction via Heme Oxygenase-1/STAT3 signaling pathway in rats. Crit Care Med 2014, 42(8):e583-94.
  60. Li H, Liu Z, Wang J, Wong GT, Cheung CW, Zhang L, Chen C, Xia Z, Irwin MG. Susceptibility to myocardial ischemia reperfusion injury at early stage of type 1 diabetes in rats. Cardiovasc Diabetol 2013, 12,133.
  61. Lei S, Li H, Xu J, Liu Y, Gao X, Wang J, Ng KF, Lau WB, Ma XL, Rodrigues B, Irwin MG, Xia Z. Hyperglycemia-induced protein kinase C beta2 activation induces diastolic cardiac dysfunction in diabetic rats by impairing caveolin-3 expression and Akt/eNOS signaling. Diabetes 2013, 62, 2318-28.
  62. Wang T, Mao X, Li H, Qiao S, Xu A, Wang J, Lei S, Liu Z, Ng KF, Wong GT, Vanhoutte PM, Irwin MG, Xia Z. N-Acetylcysteine and allopurinol up-regulated the Jak/STAT3 and PI3K/Akt pathways via adiponectin and attenuated myocardial postischemic injury in diabetes. Free Radic Biol Med 2013, 63C, 291-303.
  63. Li H, Irwin MG, Tao M, Li Y, Zhang L, Xia Z. Role of forkhead transcripition factors in myocardial ischemic reperfusion injury in diabetes. J Diabetes & Metabol 2013, 4:247.
  64. Zheng Q, Wen X, Han C, Li H, Xie X. Effect of replacing soybean meal with cottonseed meal on growth, hematology, antioxidant enzymes activity and expression for juvenile grass carp, Ctenopharyngodon idellus. Fish Physiol Biochem. 2012 38(4):1059-69.
  65. Han C, Wen X, Zheng Q, Li H. Effect of starvation on activities and mRNA expression of lipoprotein lipase and hormone-sensitive lipase in tilapia (Oreochromis niloticus x O. areus). Fish Physiol Biochem. 2011 37(1):113-22.